https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30416 Wed 11 Apr 2018 17:10:58 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26544 Wed 11 Apr 2018 15:40:57 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28251 Wed 11 Apr 2018 14:22:59 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18545 Wed 11 Apr 2018 12:52:16 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13940 Wed 11 Apr 2018 09:24:53 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26534 Wed 06 Apr 2022 14:04:50 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47819 11.0 µmol/L (p = 0.012), cysteine levels were <255 µmol/L (p = 0.033) and serum folate was <22.0 nmol/L (p = 0.003; in males only). In females, dietary intake of total folate <336 µg/day (p=0.001), natural folate <270 µg/day (p = 0.011), and vitamin B2 < 1.12 mg/day (p = 0.028) was associated with an increased AD risk. These results support Hcy, Cys, and SF as useful biomarkers for AD, irrespective of APOE4 genotype and as such should be considered as part of screening and managing risk of AD.]]> Wed 01 Feb 2023 09:58:55 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30424 Thu 28 Oct 2021 12:36:47 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:6997 T-MTHFR, 1298A>C-MTHFR, 80G>A-RFC, 2756A>G-MS, 66A>G- MSR, 19bpDHFR and 1561C>T-GCPII), only 677C>T-MTHFR was a significant risk for hypertension: OR 1.89; 95% CI 1.07–3.32 (χ² p = 0.038). Additionally, hypertensive subjects had a significantly lower intake of dietary folate than normotensive individuals (p = 0.0221), although this did not markedly alter blood metabolite levels. Several significant linear associations between dietary folate and related blood metabolites were found in normotensive subjects (p<0.001 for Hcy, red cell and serum folate) and were as predicted on an a priori basis – generally weaker associations existed in hypertensive subjects (p<0.05 for serum folate). This was true for data examined collectively or by genotype. Multiple regression analysis for diastolic or systolic blood pressure showed significant interaction for gender and folate intake (p = 0.014 and 0.019, respectively). In both cases this interaction occurred only in females, with higher folate intake associated with decreased blood pressure. Regressing diastolic blood pressure and 677C>T-MTHFR genotype showed significance (males; p = 0.032) and borderline significance (all subjects). Conclusion: Dietary folate and 677C>T-MTHFR genotype may modify blood pressure.]]> Sat 24 Mar 2018 08:37:49 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18190 Sat 24 Mar 2018 08:04:22 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17304 Sat 24 Mar 2018 08:01:49 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17921 Sat 24 Mar 2018 07:56:14 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28911 Sat 24 Mar 2018 07:26:00 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23349 Sat 24 Mar 2018 07:13:33 AEDT ]]>